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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
20
Human Site:
S316
Identified Species:
31.43
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S316
E
T
A
L
T
S
G
S
S
P
S
A
P
A
S
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S316
E
T
A
L
T
S
G
S
S
P
S
A
P
A
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S285
P
S
A
P
P
S
D
S
P
G
P
P
I
L
T
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
S300
E
T
A
L
P
S
G
S
S
S
A
P
P
S
D
Rat
Rattus norvegicus
P11345
648
72910
P235
S
Q
H
R
Y
S
T
P
H
A
F
T
F
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S296
E
T
T
L
T
S
G
S
S
P
S
A
T
P
S
Chicken
Gallus gallus
Q04982
806
89347
S316
E
T
T
P
A
S
G
S
Y
P
S
V
P
P
S
Frog
Xenopus laevis
P09560
638
71941
S225
E
S
V
R
I
P
V
S
S
Q
Q
R
Y
S
T
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
M326
G
T
T
P
I
S
E
M
C
P
S
L
P
P
S
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
V326
G
T
T
P
V
S
E
V
C
P
S
L
P
P
S
Fruit Fly
Dros. melanogaster
P11346
782
88616
A340
G
F
P
G
R
G
T
A
V
R
F
N
M
S
S
Honey Bee
Apis mellifera
XP_396892
715
80060
R293
S
P
S
L
A
P
S
R
N
Q
R
H
P
R
S
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
S353
D
K
T
G
S
L
L
S
T
Q
A
R
H
R
P
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
S312
P
D
E
P
E
S
P
S
S
D
D
Q
D
F
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
V346
K
E
I
F
K
V
V
V
P
I
G
S
L
S
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
20
N.A.
60
6.6
N.A.
80
60
20
40
40
6.6
20
6.6
20
P-Site Similarity:
100
100
N.A.
33.3
N.A.
73.3
13.3
N.A.
80
60
40
40
40
20
33.3
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
27
0
14
0
0
7
0
7
14
20
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
0
0
7
0
0
7
7
0
7
0
7
% D
% Glu:
40
7
7
0
7
0
14
0
0
0
0
0
0
0
0
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
14
0
7
7
0
% F
% Gly:
20
0
0
14
0
7
34
0
0
7
7
0
0
0
0
% G
% His:
0
0
7
0
0
0
0
0
7
0
0
7
7
0
0
% H
% Ile:
0
0
7
0
14
0
0
0
0
7
0
0
7
0
0
% I
% Lys:
7
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
34
0
7
7
0
0
0
0
14
7
7
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
0
7
0
7
0
% N
% Pro:
14
7
7
34
14
14
7
7
14
40
7
14
47
27
14
% P
% Gln:
0
7
0
0
0
0
0
0
0
20
7
7
0
0
0
% Q
% Arg:
0
0
0
14
7
0
0
7
0
7
7
14
0
14
0
% R
% Ser:
14
14
7
0
7
67
7
60
40
7
40
7
0
27
54
% S
% Thr:
0
47
34
0
20
0
14
0
7
0
0
7
7
0
20
% T
% Val:
0
0
7
0
7
7
14
14
7
0
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
7
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _